A convenient preparation of 9H-carbazole-3,6-dicarbonitrile and 9H-carbazole-3,6-dicarboxylic acid

by Ł.J. Weseliński, R. Luebke, M. Eddaoudi
Year: 2014 DOI: 10.1055/s-0033-1340557

Extra Information

Synthesis, 46 (05): 596-599, (2014)


A catalytic, high yielding and scalable procedure for the synthesis of 9H-carbazole-3,6-dicarbonitrile has been developed. Subsequent hydrolysis of the dinitrile in the presence of a catalytic copper species (i.e., CuI) yields 9H-carbazole-3,6-dicarboxylic acid. Both compounds are versatile and fine-tunable organic building blocks and therefore offer potential in material science, medicinal and supramolecular chemistry.



Carbazoles Catalytic cyanation Heterocycles Metal–organic frameworks Palladium catalysis Supramolecular chemistry