Design Strategies: Molecular Building Block (MBB) Approach

Categories: Current Research



The molecular building block (MBB) approach offers the potential to design MOFs where structural information is included into the building blocks (i.e. the organic ligands and inorganic clusters). Successful implementation of the MBB approach requires isolation of the synthetic conditions that promote the formation of a desired inorganic MBB to minimize the number of possible resulting framework topologies. Prof. Eddaoudi group seeks to leverage the knowledge that MOFs – composed of highly connected building blocks which limits the number of possible topological outcomes and thus leads to a greater degree of predictability in structure – are suitable platforms to purposely tune the resultant materials properties. Our recent work has elucidated the reaction conditions (i.e. incorporation of fluorine containing ligands or using 2-fluorobenzoic acid as a reaction modulator) necessary to promote the formation of a similar highly connected (12-connected) rare earth based hexanuclear MBB (Figure). It was shown that linking these 12-connected RE-MBBs through linear ligands results in the formation of MOFs with fcu topology. Specifically, in the hexanuclear [RE6(OH)8(O2C–)12] carboxylate-based cluster the carboxylate carbon atoms of the coordinated ligands act as points of extension and correspond to the vertices of the fcu-a net (vertex figure of the fcu net with a cuboctahedron geometry).

Related Publications

Enriching the reticular chemistry repertoire: merged nets approach for the rational design of intricate mixed-linker MOF platforms
Year: 2018 DOI:10.1021/jacs.8b04745
Authors: H. Jiang, J. Jia, A. Shkurenko, Z. Chen, K.Adil, Y. Belmabkhout, L. J. Weselinski, A. H. Assen, D-X. Xue, M. O’Keeffe, M. Eddaoudi
J. Am. Chem. Soc. 2018, 140, 28, 8858-8867
  • Reticular chemistry
  • Intricate mixed-Linker
  • Metal-organic framework
  • MOFs
Applying the power of reticular chemistry to finding the missing alb-MOF platform based on the (6,12)-coordinated edge-transitive net
Year: 2017 DOI:10.1021/jacs.7b00219
Authors: Z. Chen, Ł.J. Weseliński, K. Adil, Y. Belmabkhout, A. Shkurenko, H. Jiang, P.M. Bhatt, V. Guillerm, E. Dauzon, D.-X. Xue, M. O’Keeffe, M. Eddaoudi
J. Am. Chem. Soc. 139, 3265-3274, (2017)
  • Crystalline materials
  • Ligands
  • Organometallics
  • Prisms
  • Topology Aluminum diboride
  • Chemical systems
  • Hexagonal prism
  • Metalorganic frameworks (MOFs)
  • Molecular building blocks
Versatile rare earth hexanuclear clusters for the design and synthesis of highly-connected ftw-MOFs
Year: 2015 DOI:10.1039/C5SC00614G
Authors: R. Luebke, Y. Belmabkhout, Ł.J. Weselinski, A.J. Cairns, M. Alkordi, G. Norton, Ł. Wojtas
Chem. Sci., 6, 4095-4102, (2015)
  • Metal organic frameworks (MOFs)
Modular Chemistry: Secondary Building Units as a Basis for the Design of Highly Porous and Robust Metal−Organic Carboxylate Frameworks
Year: 2001 DOI:10.1021/ar000034b
Authors: Eddaoudi M., Moler D.B., Li H.L., Chen B.L., Reineke T.M., O'Keeffe M., Yaghi O.M.
Acc. Chem. Res., 2001, 34 (4), pp 319–330
  • MOF